Age-related chances of mitochondrial cytochrome C oxidase and F0F1-ATP synthase subunit contents in rat cerebral cortex

V G Nicoletti; E A Tendi; C Lalicata; S Reale; R F Villa; N Ragusa; A M Giuffrida-Stella

doi:10.1016/0167-4943(96)86991-3

Age-related chances of mitochondrial cytochrome C oxidase and F0F1-ATP synthase subunit contents in rat cerebral cortex

Arch Gerontol Geriatr. 1996:22 Suppl 1:509-13. doi: 10.1016/0167-4943(96)86991-3.

Authors

V G Nicoletti¹, E A Tendi, C Lalicata, S Reale, R F Villa, N Ragusa, A M Giuffrida-Stella

Affiliation

¹ Institute of Biochemistry, Faculty of Medicine, University of Catania, Viale A. Doria 6, I-95125 Catania, Italy.

PMID: 18653086
DOI: 10.1016/0167-4943(96)86991-3

Abstract

The levels of subunits I, II/III, and IV of cytochrome c oxidase and of subunits alpha, beta and gamma of F(0)F(1)-ATP synthase in inner mitochondrial membrane proteins purified from cerebral cortex of rat at 2, 6, 12, 18, 24, 26 months of age were analyzed by Western blot. Age-related changes in the content of subunits, encoded either in mitochondrial or nuclear DNA, were observed.