When involving some organ systems, sarcoidosis can affect functional outcome and/or constitute a life-threatening condition. Neurological expression is often overt and thus easily diagnosed. However, diagnosing heart involvement requires a thorough history taking and at least one systematic electrocardiogram. These lesions are serious and require a corticosteroid therapy, initiated in most cases at the daily dose of 1 mg/kg. This therapy should be combined with organ-specific treatments, always necessary though not sufficient.