Abstract
Inflammatory interleukin 1β production after silica and alum crystal or β-amyloid uptake occurs via a process involving lysosomal destabilization and release of cathepsin B that activates the NALP3 inflammasome.
MeSH terms
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / immunology*
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Adaptor Proteins, Signal Transducing / metabolism
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Adaptor Proteins, Signal Transducing / physiology
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Aging / physiology*
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Animals
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Apoptosis Regulatory Proteins / metabolism
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Apoptosis Regulatory Proteins / physiology*
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Environmental Pollution*
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Humans
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Immunity, Innate / immunology*
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Inflammation / immunology
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Inflammation / microbiology
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NLR Proteins
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Nod Signaling Adaptor Proteins / chemistry*
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Toll-Like Receptors / genetics
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Toll-Like Receptors / physiology*
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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NLR Proteins
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NLRP1 protein, human
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Nod Signaling Adaptor Proteins
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Toll-Like Receptors