NLRs and the dangers of pollution and aging

Nat Immunol. 2008 Aug;9(8):831-3. doi: 10.1038/ni0808-831.

Abstract

Inflammatory interleukin 1β production after silica and alum crystal or β-amyloid uptake occurs via a process involving lysosomal destabilization and release of cathepsin B that activates the NALP3 inflammasome.

Publication types

  • News
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / immunology*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Adaptor Proteins, Signal Transducing / physiology
  • Aging / physiology*
  • Animals
  • Apoptosis Regulatory Proteins / metabolism
  • Apoptosis Regulatory Proteins / physiology*
  • Environmental Pollution*
  • Humans
  • Immunity, Innate / immunology*
  • Inflammation / immunology
  • Inflammation / microbiology
  • NLR Proteins
  • Nod Signaling Adaptor Proteins / chemistry*
  • Toll-Like Receptors / genetics
  • Toll-Like Receptors / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • NLR Proteins
  • NLRP1 protein, human
  • Nod Signaling Adaptor Proteins
  • Toll-Like Receptors