Abstract
A highly efficient drug vector for photodynamic therapy (PDT) drug delivery was developed by synthesizing PEGylated gold nanoparticle conjugates, which act as a water-soluble and biocompatible "cage" that allows delivery of a hydrophobic drug to its site of PDT action. The dynamics of drug release in vitro in a two-phase solution system and in vivo in cancer-bearing mice indicates that the process of drug delivery is highly efficient, and passive targeting prefers the tumor site. With the Au NP-Pc 4 conjugates, the drug delivery time required for PDT has been greatly reduced to less than 2 h, compared to 2 days for the free drug.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Drug Delivery Systems*
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Gold / chemistry*
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Indoles / administration & dosage*
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Indoles / chemistry
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Isoindoles
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Metal Nanoparticles / chemistry*
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Mice
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Mice, Nude
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Neoplasms / drug therapy*
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Photochemotherapy
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Polyethylene Glycols / chemistry
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Radiation-Sensitizing Agents / administration & dosage*
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Radiation-Sensitizing Agents / chemistry
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Singlet Oxygen / analysis
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Spectrometry, Fluorescence
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Spectrophotometry, Ultraviolet
Substances
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Indoles
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Isoindoles
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Radiation-Sensitizing Agents
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Singlet Oxygen
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Polyethylene Glycols
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Gold
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phthalocyanine