Abstract
Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam prevented the development of its specific myorelaxant and sedative side effects.
MeSH terms
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Animals
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Anti-Anxiety Agents / pharmacology*
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Anticonvulsants / pharmacology*
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Benzodiazepines / pharmacology*
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Dose-Response Relationship, Drug
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Drinking / drug effects
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Hypnotics and Sedatives / administration & dosage
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Hypnotics and Sedatives / pharmacology
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Male
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Motor Activity / drug effects
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Random Allocation
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Rats
Substances
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Anti-Anxiety Agents
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Anticonvulsants
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Hypnotics and Sedatives
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Benzodiazepines
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phenazepam