Amyotrophic lateral sclerosis: combined nutritional, respiratory and functional assessment

Arq Neuropsiquiatr. 2008 Jun;66(2B):354-9. doi: 10.1590/s0004-282x2008000300014.

Abstract

Objective: To establish correlations between nutritional, functional and respiratory indices of patients with amyotrophic lateral sclerosis (ALS).

Method: Twenty patients (13 appendicular-GA and 7 bulbar-GB) were included in the multidisciplinary study at the Neurological Clinic Ambulatory of the University of Campinas Hospital.

Results: Among the GA type significant correlation was observed between maximal inspiratory (MIP) and expiratory (MEP) pressure (r=-0.76), MEP and pulse oxymetry (r=0.58), MIP and percent weight loss (%WL; r=0.59), and between MIP, total and subscale respiratory scores (ALSFRS-R) with %WL. With regard to the GB, correlation was found between MEP and body mass index (BMI) (r=0.97). In both GA and GB correlations were noticed between the BMI and the variables mass (kg), fat (%), arm and wrist circumference (cm), and tricipital, subscapular and supra-iliac skinfolds (mm), as well as the arm muscle circumference (cm) and fatty arm muscular area (mm2).

Conclusion: It is suggested that the application of simple anthropometric measurements could be useful in routine monitoring of patients with ALS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Body Mass Index*
  • Cross-Sectional Studies
  • Humans
  • Maximal Voluntary Ventilation / physiology
  • Middle Aged
  • Nutrition Assessment*
  • Nutritional Status / physiology*
  • Pulmonary Ventilation / physiology*
  • Respiratory Muscles / physiopathology
  • Respiratory System / physiopathology*
  • Severity of Illness Index