Sialyl alpha(2-->3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4405-8. doi: 10.1016/j.bmcl.2008.06.101. Epub 2008 Jul 3.

Abstract

An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl alpha(2-->3) lactose (Neu5Acalpha(2-->3)Galbeta(1-->4)Glcbeta1-->) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure-activity relationship according to the carbosilane scaffolds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Combinatorial Chemistry Techniques*
  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry
  • Dendrimers / pharmacology*
  • Drug Design*
  • Hemagglutination Tests
  • Hemagglutinin Glycoproteins, Influenza Virus / metabolism*
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Influenza A Virus, H3N2 Subtype / drug effects
  • Lactose / analogs & derivatives*
  • Lactose / chemical synthesis*
  • Lactose / chemistry
  • Lactose / pharmacology*
  • Molecular Structure
  • Parainfluenza Virus 1, Human / drug effects
  • Silanes / chemical synthesis*
  • Silanes / chemistry
  • Silanes / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Dendrimers
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Silanes
  • Lactose