MRA of the carotid arteries

Eur Radiol. 2005 Dec:15 Suppl 5:E11-6. doi: 10.1007/s10406-005-0161-2.

Abstract

Magnetic resonance angiography (MRA) is increasingly used as a non-invasive method to assess carotid arteries. Contrast-enhanced MRA (CE-MRA) has benefited from rapid technological developments, including specific hardware and pulse sequence design. In the evaluation of stenoses of the extracranial internal carotid artery (ICA), CE-MRA using "first generation" CE-MRA gadolinium (Gd)-based chelates can be a substitute for conventional digital subtraction angiography (DSA), although CE-MRA tends to overestimate the degree of stenosis. Studies describing the use of high-relaxivity contrast agents like gadobenate dimeglumine (Gd-BOPTA) reveal that this agent is safe and well tolerated for CE-MRA. The use of Gd-BOPTA shows significantly better quantitative and qualitative performance than carotid CE-MRA using first generation Gd-based chelates. In fact, CE-MRA with Gd-BOTPA provides information comparable to that attainable with rotational DSA. In conclusion, high-relaxivity contrast agents combined with dedicated MRA software appear to be optimal for achieving high-quality evaluation of the carotid arteries.

Publication types

  • Review

MeSH terms

  • Carotid Arteries*
  • Carotid Artery Diseases / diagnosis*
  • Contrast Media
  • Humans
  • Magnetic Resonance Angiography / methods*
  • Meglumine / analogs & derivatives
  • Organometallic Compounds

Substances

  • Contrast Media
  • Organometallic Compounds
  • gadobenic acid
  • Meglumine