Abstract
Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation
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Chromatin / genetics
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Chromatin / metabolism
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Embryonic Stem Cells / physiology*
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Epigenesis, Genetic*
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Gene Expression Regulation*
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Humans
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MicroRNAs / genetics
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MicroRNAs / metabolism*
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Pluripotent Stem Cells / physiology*
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Chromatin
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MicroRNAs
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Transcription Factors