Molecular basis of pluripotency

Hum Mol Genet. 2008 Apr 15;17(R1):R23-7. doi: 10.1093/hmg/ddn050.

Abstract

Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chromatin / genetics
  • Chromatin / metabolism
  • Embryonic Stem Cells / physiology*
  • Epigenesis, Genetic*
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Pluripotent Stem Cells / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • MicroRNAs
  • Transcription Factors