Successful treatment for chromoblastomycosis caused by Fonsecaea monophora: a report of three cases in Guangdong, China

Mycoses. 2009 Mar;52(2):176-81. doi: 10.1111/j.1439-0507.2008.01547.x. Epub 2008 Jun 21.

Abstract

Fonsecaea pedrosoi is the most prevalent aetiological agent of chromoblastomycosis. Fonsecaea monophora is a new species segregated from Fonsecaea pedrosoi. Herein, we report on three cases of chromoblastomycosis caused by F. monophora that were successfully treated with terbinafine and/or itraconazole. Clinical characteristics and mycological parameters are described. Two of the three patients underwent combination therapy with itraconazole and terbinafine during early stages of treatment and were completely healed in a relatively short course of treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents* / administration & dosage
  • Antifungal Agents* / therapeutic use
  • Ascomycota / classification
  • Ascomycota / drug effects*
  • Ascomycota / isolation & purification
  • China
  • Chromoblastomycosis / drug therapy*
  • Chromoblastomycosis / microbiology
  • Chromoblastomycosis / pathology
  • Drug Therapy, Combination
  • Face / microbiology
  • Face / pathology
  • Humans
  • Itraconazole* / administration & dosage
  • Itraconazole* / therapeutic use
  • Leg Dermatoses / drug therapy*
  • Leg Dermatoses / microbiology
  • Leg Dermatoses / pathology
  • Male
  • Middle Aged
  • Naphthalenes* / administration & dosage
  • Naphthalenes* / therapeutic use
  • Terbinafine
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Naphthalenes
  • Itraconazole
  • Terbinafine