Monoolein-water liquid crystalline gels of gentamicin as bioresorbable implants for the local treatment of chronic osteomyelitis: in vitro characterization

Drug Dev Ind Pharm. 2008 Jul;34(7):753-60. doi: 10.1080/03639040801926287.

Abstract

To maximize the efficacy of chronic osteomyelitis antibiotherapy while reducing antibiotic systemic toxicity, as well as time and costs of hospitalizations, it has been thought that monoolein-water gels incorporating gentamicin sulfate could be used as local, bioresorbable,and sustained-release implants. For this purpose, four formulations were examined with regard to their physicochemical and in vitro drug release characteristics. Hot stage microscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA),and X-ray diffraction showed cubic liquid crystalline and eutectic structures. The more suitable formulation consisting of 80-15-5%wt/wt monoolein-water-gentamicin sulfate progressively released the antibiotic for a period of 3 weeks without burst effect. Moreover, the content and the release profile of gentamicin sulfate were not significantly changed after storage at 2-6 degrees C for a period of 10 months.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / chemistry
  • Calorimetry, Differential Scanning
  • Chemistry, Pharmaceutical
  • Chronic Disease
  • Crystallization
  • Delayed-Action Preparations
  • Drug Implants
  • Drug Stability
  • Drug Storage
  • Gentamicins / administration & dosage*
  • Gentamicins / chemistry
  • Microscopy / methods
  • Osteomyelitis / drug therapy*
  • Solubility
  • Thermogravimetry
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Delayed-Action Preparations
  • Drug Implants
  • Gentamicins