Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

Keelara Abiraj; Hugues Jaccard; Martin Kretzschmar; Lothar Helm; Helmut R Maecke

doi:10.1039/b805281f

Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

Chem Commun (Camb). 2008 Jul 28:(28):3248-50. doi: 10.1039/b805281f. Epub 2008 Jun 20.

Authors

Keelara Abiraj¹, Hugues Jaccard, Martin Kretzschmar, Lothar Helm, Helmut R Maecke

Affiliation

¹ Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

PMID: 18622433
DOI: 10.1039/b805281f

Abstract

Dimeric peptidic vectors, obtained by the divalent grafting of bombesin analogues on a newly synthesized DOTA-based prochelator, showed improved qualities as tumor targeted imaging probes in comparison to their monomeric analogues.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Bombesin / analogs & derivatives*
Bombesin / chemical synthesis*
Bombesin / therapeutic use
Chelating Agents / chemical synthesis*
Chelating Agents / chemistry
Dimerization
Heterocyclic Compounds, 1-Ring / chemistry*
Humans
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Chelating Agents
Heterocyclic Compounds, 1-Ring
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
Bombesin