Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

T D Venu; S A Khanum; Aiysha Firdouse; B K Manuprasad; Sheena Shashikanth; Riyaz Mohamed; Bannikuppe Sannanaik Vishwanth

doi:10.1016/j.bmcl.2008.06.061

Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4409-12. doi: 10.1016/j.bmcl.2008.06.061. Epub 2008 Jun 20.

Authors

T D Venu¹, S A Khanum, Aiysha Firdouse, B K Manuprasad, Sheena Shashikanth, Riyaz Mohamed, Bannikuppe Sannanaik Vishwanth

Affiliation

¹ Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570 006, India.

PMID: 18621525
DOI: 10.1016/j.bmcl.2008.06.061

Abstract

Reaction of 6a-f individually with 2-methylsulfonyl-4,6-dimethoxypyrimidine yielded 7a-f in excellent yield. The newly synthesized heterocycles were characterized by IR, (1)H NMR, and mass spectral data. Compounds 7a-f was screened for their anti-inflammatory activity and were compared with standard drugs. Of the compounds studied, the compound 7e showed more potent activity than the standard drugs at all doses tested.

MeSH terms

Algorithms
Animals
Animals, Inbred Strains
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Disease Models, Animal
Edema / chemically induced
Edema / drug therapy
Edema / prevention & control
Foot / pathology
Mice
Phospholipases A2 / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Pyrimidines / chemical synthesis*
Pyrimidines / chemistry
Pyrimidines / pharmacology*
Rats
Ulcer / etiology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Pyrimidines
Prostaglandin-Endoperoxide Synthases
Phospholipases A2