Abstract
This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
MeSH terms
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Combinatorial Chemistry Techniques
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Molecular Structure
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Protein-Arginine N-Methyltransferases / antagonists & inhibitors*
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Pyrazoles
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Protein-Arginine N-Methyltransferases
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coactivator-associated arginine methyltransferase 1