NMR studies of novel Schiff bases derived from L-alpha-amino methyl esters and 3-hydroxypyridin-4-carboxaldehyde

Magn Reson Chem. 2008 Oct;46(10):930-8. doi: 10.1002/mrc.2278.

Abstract

Schiff bases of 3-hydroxypyridin-4-carboxaldehyde and L-alpha-amino esters as well as those derived from the structurally related amines lacking the ester function have been synthesised. In two cases a tetrahydro-1H-imidazo[4,5-c]pyridine was formed as a by-product. (1)H, (13)C, (15)N-NMR spectral data and density functional theory (DFT) calculations established the structure of all compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Esters / chemistry*
  • Isoxazoles / chemical synthesis
  • Isoxazoles / chemistry*
  • Magnetic Resonance Spectroscopy / methods*
  • Magnetic Resonance Spectroscopy / standards
  • Models, Chemical
  • Molecular Structure
  • Reference Standards
  • Schiff Bases / chemical synthesis
  • Schiff Bases / chemistry*
  • Sensitivity and Specificity
  • Stereoisomerism

Substances

  • Amino Acids
  • Esters
  • Isoxazoles
  • Schiff Bases