Amyloidosis is one of the unusual diseases which may still be underdiagnosed when it is affecting the patient. During the last three decades, an enormous progress has been made in understanding and improvement of the biochemical nature, classification, pathogenesis, clinical features, diagnostic measures and rational therapy of this disorder. The varied clinical presentation of gastrointestinal amyloidosis makes the diagnosis challenging. It should be considered in patients older than 30 years with otherwise unexplained diarrhoea, weight loss, motility dysfunction or malabsorption.