Familial myeloma

N Engl J Med. 2008 Jul 10;359(2):152-7. doi: 10.1056/NEJMoa0708704.

Abstract

We describe a family with five cases of multiple myeloma, three cases of monoclonal gammopathy of undetermined significance (MGUS), and five cases of prostate cancer in two generations. The putative progenitor had progeny with two female partners. The progeny had prostate cancer, multiple myeloma, and MGUS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Black People / genetics
  • Female
  • Humans
  • Immunoglobulin kappa-Chains / blood
  • Immunoglobulin lambda-Chains / blood
  • Male
  • Middle Aged
  • Multiple Myeloma / genetics*
  • Neoplastic Syndromes, Hereditary*
  • Paraproteinemias / blood
  • Paraproteinemias / genetics*
  • Paraproteinemias / immunology
  • Pedigree
  • Prostatic Neoplasms / genetics*

Substances

  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains