Purpose: To provide a clinical tool for calculating a patient's future risk for developing cognitive impairment based on age, family history, and Rey Auditory Verbal Learning Test (AVLT) retention.
Participants: 1,019 cognitively normal persons followed for an average of 5 years; 159 participants were eventually diagnosed with cognitive impairment.
Results: Risk of developing cognitive impairment increases with age and family history, but decreases with better memory performance. A nomogram is provided for calculation of relative risk of developing cognitive impairment in combinations of age, family history, and memory performance.
Conclusions: These results enhance clinicians' ability to provide information to a patient about risk of cognitive impairment.