Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues

You Wang; Feiran Zhang; Yihua Zhang; Jun O Liu; Dawei Ma

doi:10.1016/j.bmcl.2008.06.066

Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4385-7. doi: 10.1016/j.bmcl.2008.06.066. Epub 2008 Jun 21.

Authors

You Wang¹, Feiran Zhang, Yihua Zhang, Jun O Liu, Dawei Ma

Affiliation

¹ Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.

PMID: 18606540
DOI: 10.1016/j.bmcl.2008.06.066

Abstract

The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alanine / chemistry
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Biological Products / chemical synthesis*
Biological Products / chemistry
Biological Products / pharmacology
Cell Line, Tumor
Depsipeptides / chemical synthesis*
Depsipeptides / chemistry
Depsipeptides / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Structure-Activity Relationship

Substances

Antineoplastic Agents
Biological Products
Depsipeptides
zygosporamide
Alanine