A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling

Katharine H Wrighton; Fangyan Dai; Xin-Hua Feng

doi:10.1016/j.devcel.2008.06.010

A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling

Dev Cell. 2008 Jul;15(1):8-10. doi: 10.1016/j.devcel.2008.06.010.

Authors

Katharine H Wrighton¹, Fangyan Dai, Xin-Hua Feng

Affiliation

¹ Michael E. DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

PMID: 18606136
DOI: 10.1016/j.devcel.2008.06.010

Abstract

A recent study from Varelas et al. in Nature Cell Biology reveals a role for the transcriptional regulator TAZ in TGFbeta signaling. Not only does TAZ couple phospho-Smads to the transcriptional machinery, it is also essential for their nuclear accumulation.

MeSH terms

Active Transport, Cell Nucleus
Acyltransferases
Bone Morphogenetic Proteins / metabolism
Cell Nucleus / metabolism*
Cytoplasm / metabolism
Humans
Models, Biological
Phosphorylation
Signal Transduction*
Smad Proteins / metabolism*
Transcription Factors / genetics
Transcription Factors / metabolism*
Transcription, Genetic
Transforming Growth Factor beta / metabolism*

Substances

Bone Morphogenetic Proteins
Smad Proteins
Transcription Factors
Transforming Growth Factor beta
Acyltransferases
TAFAZZIN protein, human