Indomethacin release in relation to the concentration of pharmaceutical excipients

M Potúcková; Z Vitková; E Tichý; V Simunková

Indomethacin release in relation to the concentration of pharmaceutical excipients

Pharmazie. 2008 Jun;63(6):485-6.

Authors

M Potúcková¹, Z Vitková, E Tichý, V Simunková

Affiliation

¹ Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. vercimakova@fpharm.uniba.sk

PMID: 18604995

Abstract

Indomethacin in vitro release was investigated in relation to the concentration of the pharmaceutical excipients, such as ethanol and propylene glycol. Drug release was studied from gels containing Sepigel 305 as a gelling agent. Not only the concentration of ethanol and propylene glycol influence the rate of indomethacin release, but also Sepigel 305 significantly increased the amount of indomethacin release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics*
Ethanol
Excipients
Indomethacin / administration & dosage*
Indomethacin / pharmacokinetics*
Kinetics
Propylene Glycols
Solvents

Substances

Anti-Inflammatory Agents, Non-Steroidal
Excipients
Propylene Glycols
Solvents
Ethanol
Indomethacin