Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity

Toxicology. 2009 Sep 1;263(1):20-5. doi: 10.1016/j.tox.2008.06.002. Epub 2008 Jun 18.

Abstract

Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkylation
  • Apoptosis / drug effects
  • Chemical Warfare Agents / chemistry
  • Chemical Warfare Agents / metabolism
  • Chemical Warfare Agents / poisoning*
  • DNA / chemistry
  • DNA / drug effects
  • DNA / metabolism
  • DNA Adducts / chemistry
  • DNA Repair
  • Enzyme Inhibitors
  • Humans
  • Mustard Gas / chemistry
  • Mustard Gas / metabolism
  • Mustard Gas / poisoning*
  • Poisoning / enzymology*
  • Poisoning / etiology
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases / physiology*
  • Skin Absorption

Substances

  • Chemical Warfare Agents
  • DNA Adducts
  • Enzyme Inhibitors
  • DNA
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases
  • Mustard Gas