Abstract
Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkylation
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Apoptosis / drug effects
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Chemical Warfare Agents / chemistry
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Chemical Warfare Agents / metabolism
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Chemical Warfare Agents / poisoning*
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DNA / chemistry
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DNA / drug effects
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DNA / metabolism
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DNA Adducts / chemistry
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DNA Repair
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Enzyme Inhibitors
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Humans
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Mustard Gas / chemistry
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Mustard Gas / metabolism
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Mustard Gas / poisoning*
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Poisoning / enzymology*
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Poisoning / etiology
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Poly (ADP-Ribose) Polymerase-1
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Poly(ADP-ribose) Polymerases / physiology*
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Skin Absorption
Substances
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Chemical Warfare Agents
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DNA Adducts
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Enzyme Inhibitors
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DNA
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PARP1 protein, human
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Poly (ADP-Ribose) Polymerase-1
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Poly(ADP-ribose) Polymerases
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Mustard Gas