Infectious spondylodiscitis due to Candida species is rarely reported, not well known entity with low frequency. Most probably its frequency is underestimated, partly because of chronic course and difficulties with establishing of final diagnosis. Candida can be considered as the opportunistic pathogens. The infection proceeds as the systemic mycosis and most commonly develops in individuals with immune deficiency. In forthcoming years, the higher frequency of opportunistic infections, including mycotic spondylodiscitis, can be expected because of an increasing number of individuals treated with immunosuppressive drugs, and an increasing number of medical invasive procedures. A purpose of our paper is to describe a natural history of infectious spondylodiscitis due to Candida, usefull diagnostic methods, and recommended treatment.