Synthesis, characterization, and the antioxidative activity of 4-{[(3,4-dimethyl pyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and Its zinc(II), copper(II), nickel(II) complexes

Chem Pharm Bull (Tokyo). 2008 Jul;56(7):1018-21. doi: 10.1248/cpb.56.1018.

Abstract

A new ligand H(3)L, 4-{[(3,4-dimethylpyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and its three transition metal complexes, M(H(2)L)OAc.H(2)O (M=Cu, Ni), Zn(H(2)L)(2) have been synthesized and fully characterized on the basis of ESI-MS, elemental analyses, molar conductivities, IR spectra and (1)H-NMR. In addition, their antioxidative activities have been investigated by spectrophotometer measurements. The experimental results show that the complexes have higher activity in the suppression of O(2)(*-) and *OH than the free ligand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Copper
  • Free Radical Scavengers / chemical synthesis
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • Hydrazines / chemical synthesis*
  • Hydrazines / chemistry
  • Hydrazines / pharmacology
  • Hydroxyl Radical / metabolism
  • Nickel
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Pyrroles / pharmacology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Superoxides / metabolism
  • Zinc

Substances

  • 4-(((3,4-dimethyl pyrrole-2-carbonyl)hydrazono)(phenyl)methyl)-3-methyl-1-phenylpyrazol-5-ol
  • Antioxidants
  • Free Radical Scavengers
  • Hydrazines
  • Organometallic Compounds
  • Pyrazoles
  • Pyrroles
  • Superoxides
  • Hydroxyl Radical
  • Copper
  • Nickel
  • Zinc