Abstract
A new ligand H(3)L, 4-{[(3,4-dimethylpyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and its three transition metal complexes, M(H(2)L)OAc.H(2)O (M=Cu, Ni), Zn(H(2)L)(2) have been synthesized and fully characterized on the basis of ESI-MS, elemental analyses, molar conductivities, IR spectra and (1)H-NMR. In addition, their antioxidative activities have been investigated by spectrophotometer measurements. The experimental results show that the complexes have higher activity in the suppression of O(2)(*-) and *OH than the free ligand.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antioxidants / chemical synthesis*
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Copper
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Hydrazines / chemical synthesis*
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Hydrazines / chemistry
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Hydrazines / pharmacology
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Hydroxyl Radical / metabolism
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Nickel
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
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Pyrroles / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Superoxides / metabolism
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Zinc
Substances
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4-(((3,4-dimethyl pyrrole-2-carbonyl)hydrazono)(phenyl)methyl)-3-methyl-1-phenylpyrazol-5-ol
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Antioxidants
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Free Radical Scavengers
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Hydrazines
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Organometallic Compounds
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Pyrazoles
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Pyrroles
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Superoxides
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Hydroxyl Radical
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Copper
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Nickel
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Zinc