Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition

Trends Cell Biol. 2008 Aug;18(8):357-9. doi: 10.1016/j.tcb.2008.05.005. Epub 2008 Jun 26.

Abstract

Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Embryonic Development
  • Epithelial Cells*
  • Gene Expression Regulation
  • Homeodomain Proteins / genetics
  • Humans
  • Mesenchymal Stem Cells*
  • MicroRNAs / physiology
  • Neoplasms / genetics
  • Neoplasms / pathology
  • RNA, Antisense / physiology*
  • Repressor Proteins / genetics
  • Transcription Factors / genetics
  • Zinc Finger E-box Binding Homeobox 2
  • Zinc Finger E-box-Binding Homeobox 1

Substances

  • Homeodomain Proteins
  • MicroRNAs
  • RNA, Antisense
  • Repressor Proteins
  • Transcription Factors
  • ZEB1 protein, human
  • ZEB2 protein, human
  • Zinc Finger E-box Binding Homeobox 2
  • Zinc Finger E-box-Binding Homeobox 1