Oil-gas exploration and production (E&P) soils contaminated with total petroleum hydrocarbons (TPHs) have been tested for degradation by two different treatments: biological and chemical. Biological treatment includes the use of native microorganisms for transformation of the various hydrocarbons found in E&P soils. Degradation of TPH of 80 and 86%, was achieved for two different soils, respectively in control experiments. The effect of growth stimulants such as glucose, acetic acid, and valeric acid was examined on TPH degradation. Incorporation of inducer (valerate) enhanced the degradation up to 89 and 93%, for the two soils, respectively. A large portion (> 41%) of contaminant in one soil was comprised of compounds in the carbon range of C10-C16 and < 7% constituted carbon range of C24-C28. The degradation of C10-C16 compounds was higher (> 98%) as compared to C24-C28 compounds (< 75%). Likewise, the degradation rate was also higher (58 mg/kg/d) for lower compounds as compared to higher carbon range compounds (6.7 mg/kg/d). Experiments conducted on chemical treatment included the effect of chelators on stabilization of H2O2, comparative studies between buffer and water (used for soil preparation), and the effect of pH on TPH degradation. The rate of oxygen evolution from H2O2 was significantly reduced with use of either chelated iron or phosphate buffer using naphthelene as a model compound. Chemical treatment demonstrated a higher degradation of TPH from contaminated soils at pH 4.0 as compared to a pH of 7.0. More degradation was obtained with slurry prepared in phosphate buffer as compared to deionized water.