Abstract
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H(2)O(2), and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H(2)O(2)) and fluconazole demonstrated that the combination had enhanced efficacy.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antifungal Agents / pharmacology*
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Biofilms / drug effects*
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Biofilms / growth & development
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Candida / drug effects
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Candida / growth & development
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Candida albicans / drug effects*
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Candida albicans / growth & development
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Candida glabrata / drug effects
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Candida glabrata / growth & development
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Disinfectants / pharmacology*
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Drug Interactions
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Drug Resistance, Fungal
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Drug Therapy, Combination
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Ethanol / pharmacology
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Fluconazole / pharmacology*
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Humans
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Hydrogen Peroxide / pharmacology
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Microbial Sensitivity Tests
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Sodium Dodecyl Sulfate / pharmacology
Substances
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Antifungal Agents
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Disinfectants
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Sodium Dodecyl Sulfate
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Ethanol
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Fluconazole
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Hydrogen Peroxide