Abstract
These studies were performed to determine the effect of AD-472, an attenuated human herpes simplex virus (HSV) type 2 or HSV-2 glycoprotein D (gD) when combined with an adjuvant, GPI-0100, a semi-synthetic Quillaja Saponin analog in a genital HSV-2 infection in guinea pigs. While animals immunized with either vaccine had reduced clinical disease, GPI-0100 only improved the efficacy of gD and did not affect the efficacy of the live vaccine. Neither vaccine had any therapeutic effect if administered 24 h after viral infection.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic*
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Animals
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Female
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Guinea Pigs
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Herpes Genitalis / immunology
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Herpes Genitalis / prevention & control*
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Herpes Simplex Virus Vaccines / immunology*
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Herpesvirus 2, Human / immunology*
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Humans
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Saponins / immunology*
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Vaccination*
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Vaccines, Attenuated / immunology*
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Viral Envelope Proteins / immunology*
Substances
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Adjuvants, Immunologic
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GPI0100
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Herpes Simplex Virus Vaccines
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Saponins
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Vaccines, Attenuated
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Viral Envelope Proteins
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glycoprotein D-herpes simplex virus type 2