The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin
Polim Med. 2007;37(4):59-64.
[Article in
English,
Polish]
Affiliation
- 1 Department of Pharmaceutical Technology, Wrocław Medical University. szczesniak@gmail.com
Abstract
Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.
MeSH terms
-
Acetamides / chemistry
-
Anti-Inflammatory Agents / pharmacokinetics*
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Biological Availability
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Gels / chemistry
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Hydrogels / pharmacokinetics
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Pharmaceutical Vehicles / chemistry
-
Polysorbates / chemistry
-
Prednisolone / pharmacokinetics*
-
Propylene Glycol / chemistry
-
beta-Cyclodextrins / pharmacokinetics*
Substances
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Acetamides
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Anti-Inflammatory Agents
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Gels
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Hydrogels
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Pharmaceutical Vehicles
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Polysorbates
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beta-Cyclodextrins
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Propylene Glycol
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Prednisolone
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dimethylacetamide
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betadex