The effect of hydrophilic base on pharmaceutical availability of prednisolone complexed with beta-cyclodextrin

Polim Med. 2007;37(4):59-64.
[Article in English, Polish]

Abstract

Studies on the effect of hydrophilic gel composition on pharmaceutical availability of prednisolone complexed with beta-cyklodextrin at P:beta-CD ratios 1:1 and 1:2 revealed that the half-release times were shortened and differentiated depending on the substances added hydrogel to propylene glycol, dimethylacetamide and polysorbate 20 in comparison to preparations containing non-complexed active substance.

Publication types

  • Comparative Study

MeSH terms

  • Acetamides / chemistry
  • Anti-Inflammatory Agents / pharmacokinetics*
  • Biological Availability
  • Gels / chemistry
  • Hydrogels / pharmacokinetics
  • Pharmaceutical Vehicles / chemistry
  • Polysorbates / chemistry
  • Prednisolone / pharmacokinetics*
  • Propylene Glycol / chemistry
  • beta-Cyclodextrins / pharmacokinetics*

Substances

  • Acetamides
  • Anti-Inflammatory Agents
  • Gels
  • Hydrogels
  • Pharmaceutical Vehicles
  • Polysorbates
  • beta-Cyclodextrins
  • Propylene Glycol
  • Prednisolone
  • dimethylacetamide
  • betadex