You're too old for that

Vinay A Shah; Sandeep Randhawa; Thomas Mizen; Andrew G Lee; Rod Foroozan

doi:10.1016/j.survophthal.2008.04.003

You're too old for that

Surv Ophthalmol. 2008 Jul-Aug;53(4):403-10. doi: 10.1016/j.survophthal.2008.04.003.

Authors

Vinay A Shah¹, Sandeep Randhawa, Thomas Mizen, Andrew G Lee, Rod Foroozan

Affiliation

¹ Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1091, USA.

PMID: 18572056
DOI: 10.1016/j.survophthal.2008.04.003

Abstract

Leber hereditary optic neuropathy (LHON) produces a subacute and typically bilateral but sequential optic neuropathy. LHON is a mitochondrial disease and the most common mutations are at positions 11778, 14484 and 3460. LHON typically presents in young (age 20-40), healthy men but may occur in either sex and at any age. We report a case of LHON in a 72-year-old man and we emphasize the importance of testing for LHON in all cases of unexplained bilateral and sequential optic neuropathy with a ceco-central or central scotoma.

Publication types

Case Reports
Clinical Conference

MeSH terms

Age Factors
Aged
Drug Therapy, Combination
Humans
Immunosuppressive Agents / therapeutic use
Magnetic Resonance Imaging
Male
Methotrexate / therapeutic use
Optic Atrophy, Hereditary, Leber / diagnosis*
Optic Atrophy, Hereditary, Leber / drug therapy
Optic Nerve / pathology*
Prednisone / therapeutic use
Scotoma / diagnosis*
Visual Field Tests
Visual Fields*

Substances

Immunosuppressive Agents
Prednisone
Methotrexate