Solid-phase synthesis of a lysine-capped bis-dendron with remarkable DNA delivery abilities

Org Biomol Chem. 2008 Jul 7;6(13):2266-9. doi: 10.1039/b804771e. Epub 2008 May 12.

Abstract

Solid-phase synthesis of a generation 3.0 polyamidourea 1-->3 C-branched bis-dendron followed by capping of the peripheral amino groups with L-lysine gave an efficient transfection reagent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • DNA / chemistry
  • DNA / genetics*
  • Dendrimers / chemical synthesis*
  • Dendrimers / chemistry
  • Dendrimers / metabolism*
  • Electrophoresis
  • Gene Transfer Techniques / instrumentation*
  • Humans
  • Lysine / chemistry*

Substances

  • Dendrimers
  • DNA
  • Lysine