Abstract
In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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DNA Gyrase / genetics
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DNA Gyrase / metabolism
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Genotype
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / enzymology
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Mycobacterium tuberculosis / genetics
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Ofloxacin / pharmacology*
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Russia
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Tuberculosis, Multidrug-Resistant / genetics*
Substances
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Antitubercular Agents
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Bacterial Proteins
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Ofloxacin
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DNA Gyrase