Abstract
A new pyran derivative, 6-hydroxy-2H-pyran-3-carbaldehyde, has been isolated from the methanolic extract of Crinum yemense along with the known alkaloid haemanthamine, benzoic acid and 1,1'-bis(1,1'-carboxyethyl) ether which is isolated from a natural source for the first time. Structure elucidation of these compounds based on spectroscopicevidences. The pyran derivative was found to be a tyrosinase inhibitor more potent than kojic acid.
MeSH terms
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Agaricus / enzymology
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Aldehydes / isolation & purification*
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Aldehydes / therapeutic use*
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Crinum / chemistry*
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / therapeutic use*
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Hyperpigmentation / drug therapy*
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Levodopa / metabolism
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Magnetic Resonance Spectroscopy
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Melanins / biosynthesis
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Monophenol Monooxygenase / antagonists & inhibitors*
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Plant Roots / chemistry
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Pyrans / isolation & purification*
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Pyrans / therapeutic use*
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Pyrones / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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6-hydroxy-2H-pyran-3-carbaldehyde
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Aldehydes
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Enzyme Inhibitors
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Melanins
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Pyrans
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Pyrones
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Levodopa
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kojic acid
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Monophenol Monooxygenase