Abstract
Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bacillus subtilis / drug effects
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Drug Screening Assays, Antitumor
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Enterococcus faecalis / drug effects
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Gossypol / chemistry
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Gossypol / isolation & purification
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Gossypol / pharmacology
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Humans
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Malvaceae / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthoquinones / chemistry
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Naphthoquinones / isolation & purification*
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Naphthoquinones / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology*
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Staphylococcus aureus / drug effects
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Thailand
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Wood / chemistry
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Naphthoquinones
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Sesquiterpenes
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mansonone E
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Gossypol