Regulation of mitochondrial antiviral signaling pathways

Immunity. 2008 Jun;28(6):735-9. doi: 10.1016/j.immuni.2008.05.005.

Abstract

Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cytokines / metabolism*
  • Humans
  • Interferon Type I / immunology
  • Interferon Type I / metabolism
  • Mitochondria / immunology
  • Mitochondria / metabolism*
  • RNA Helicases / metabolism*
  • RNA, Viral / metabolism*
  • Receptors, Pattern Recognition / metabolism*
  • Signal Transduction*
  • Toll-Like Receptors / metabolism
  • Viruses / immunology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Cytokines
  • Interferon Type I
  • MAVS protein, human
  • RNA, Viral
  • Receptors, Pattern Recognition
  • Toll-Like Receptors
  • RNA Helicases