Abstract
Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.
MeSH terms
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Adaptor Proteins, Signal Transducing / immunology
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Cytokines / metabolism*
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Humans
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Interferon Type I / immunology
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Interferon Type I / metabolism
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Mitochondria / immunology
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Mitochondria / metabolism*
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RNA Helicases / metabolism*
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RNA, Viral / metabolism*
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Receptors, Pattern Recognition / metabolism*
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Signal Transduction*
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Toll-Like Receptors / metabolism
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Viruses / immunology*
Substances
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Adaptor Proteins, Signal Transducing
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Cytokines
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Interferon Type I
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MAVS protein, human
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RNA, Viral
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Receptors, Pattern Recognition
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Toll-Like Receptors
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RNA Helicases