Cluster detection based on spatial associations and iterated residuals in generalized linear mixed models

Biometrics. 2009 Jun;65(2):353-60. doi: 10.1111/j.1541-0420.2008.01069.x. Epub 2008 May 11.

Abstract

Spatial clustering is commonly modeled by a Bayesian method under the framework of generalized linear mixed effect models (GLMMs). Spatial clusters are commonly detected by a frequentist method through hypothesis testing. In this article, we provide a frequentist method for assessing spatial properties of GLMMs. We propose a strategy that detects spatial clusters through parameter estimates of spatial associations, and assesses spatial aspects of model improvement through iterated residuals. Simulations and a case study show that the proposed method is able to consistently and efficiently detect the locations and magnitudes of spatial clusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Biometry / methods*
  • Cluster Analysis*
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Epidemiologic Research Design*
  • Linear Models*
  • Pattern Recognition, Automated
  • Proportional Hazards Models
  • Reproducibility of Results
  • Risk Assessment / methods*
  • Sensitivity and Specificity