Global behaviour of an age-infection-structured HIV model with impulsive drug-treatment strategy

J Theor Biol. 2008 Aug 21;253(4):749-54. doi: 10.1016/j.jtbi.2008.04.021. Epub 2008 Apr 29.

Abstract

In this paper, we develop an HIV model that considers the dependence of HIV/AIDS progress on infection age (duration since infection), chronological age and impulsive antiretroviral treatment. The analytical results show that there exists a globally asymptotically stable infection-free state when the impulsive period T and drug-treatment proportion p satisfy R(0)(p,T)<1. The numerical simulation results indicate that there exist T and p such that R(0)(p,T)<1. Due to pulses, it would be difficult to obtain the optimal pulse interval in the age distribution of population. However, our results demonstrate the effect of the impulsive drug-treatment strategy on the dynamics of HIV/AIDS.

MeSH terms

  • Aging / physiology
  • Anti-Retroviral Agents / therapeutic use
  • Computer Simulation*
  • Disease Susceptibility
  • Global Health*
  • HIV Infections / drug therapy
  • HIV Infections / prevention & control
  • HIV Infections / transmission*
  • Humans
  • Models, Biological
  • Models, Statistical*
  • Time

Substances

  • Anti-Retroviral Agents