Oral immunization with Salmonella harboring a Sm14-based DNA vaccine does not protect mice against Schistosoma mansoni infection

Parasitol Int. 2008 Dec;57(4):506-8. doi: 10.1016/j.parint.2008.04.010. Epub 2008 Apr 26.

Abstract

The protection against Schistosoma mansoni infection was evaluated in SWISS mice orally vaccinated with an attenuated strain of Salmonella carrying a Sm14-based DNA vaccine. Although this formulation was not able to afford a reduction in the worm burden, a non-antigen-specific decrease in schistosome-induced granulomatous reaction was verified in livers of mice that received Salmonella.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Fatty Acid Transport Proteins / administration & dosage
  • Fatty Acid Transport Proteins / genetics*
  • Female
  • Granuloma / parasitology
  • Granuloma / pathology
  • Granuloma / prevention & control
  • Helminth Proteins / administration & dosage
  • Helminth Proteins / genetics*
  • Immunization
  • Liver / parasitology
  • Liver / pathology
  • Mice
  • Plasmids / genetics
  • Salmonella typhimurium / genetics*
  • Schistosoma mansoni / immunology*
  • Schistosomiasis mansoni / parasitology
  • Schistosomiasis mansoni / pathology
  • Schistosomiasis mansoni / prevention & control*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / genetics
  • Vaccines, DNA / administration & dosage*

Substances

  • Fatty Acid Transport Proteins
  • Helminth Proteins
  • Vaccines, Attenuated
  • Vaccines, DNA
  • SM14 protein, Schistosoma mansoni