Taxanes and gene expression in breast cancer cells

Jolanta Rzymowska; Piotr Maj; Maciej Niemczyk; Tadeusz Malewski; Andrzej Wilkołaski

Taxanes and gene expression in breast cancer cells

Acta Pol Pharm. 2008 Jan-Feb;65(1):153-7.

Authors

Jolanta Rzymowska¹, Piotr Maj, Maciej Niemczyk, Tadeusz Malewski, Andrzej Wilkołaski

Affiliation

¹ Department of Biology and Genetics, Medical University, Lublin, Poland.

PMID: 18536190

Abstract

We analyzed expression of genes participating in apoptotic and oncogenesis processes under influence of paclitaxel applied in treatment of breast carcinoma. Analysis showed, that in a group of cells where paclitaxel was administered at lower dose (60 ng/mL) it caused statistically significant increase of expression of pro and antiapoptotic genes, genes coding caspases and oncogenes in comparison to control group.

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Breast Neoplasms / drug therapy*
Breast Neoplasms / genetics
Caspases / drug effects
Female
Gene Expression Regulation, Neoplastic / drug effects*
Humans
Oligonucleotide Array Sequence Analysis
Oncogenes / drug effects
Paclitaxel / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Caspases
Paclitaxel