Abstract
A series of 1-(2,4-dinitrophenyl)-3-(3-nitrophenyl)-5-(4-substituted phenyl)-2-pyrazolin-4-ones (4a-e) have been synthesized by the oxidation of 1-(2,4-dinitrophenyl)-3-(3-nitrophenyl)-5-(4-substituted phenyl)-4-bromo-2-pyrazolines (3a-e) with dimethylsulfoxide. The structure has been established on the basis of spectral data (IR,1H NMR). The synthesized compounds have been screened in vitro for their possible antimicrobial activity.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pyrazoles / chemical synthesis
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Pyrazoles / pharmacology*
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Transition Temperature
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Pyrazoles