Aspirin decreases the prevalence and severity of heterotopic ossification after 1-stage bilateral total hip arthroplasty for osteoarthrosis

J Arthroplasty. 2009 Feb;24(2):226-32. doi: 10.1016/j.arth.2007.11.008. Epub 2008 Mar 28.

Abstract

Heterotopic ossification (HO) is a frequent complication after total hip arthroplasty (THA). We retrospectively evaluated the prevalence and severity of HO in patients with osteoarthrosis who underwent 1-stage bilateral THA (OSBTHA) and compared those who received aspirin with those who received Coumadin for postoperative chemothromboprophylaxis. The aspirin group consisted of 66 patients (132 hips), with a mean age of 64 years (SD, 8.5). The Coumadin group consisted of 67 patients (134 hips), with a mean age of 60 years (SD, 10.2). Overall, HO was detected in 124 hips (46.6%). There were 43 hips (32.5%) with HO in the aspirin group and 81 (60.4%) in the Coumadin group (P < .00005). Aspirin significantly decreases the prevalence and severity of HO in comparison to Coumadin after OSBTHA.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Anticoagulants / therapeutic use
  • Arthroplasty, Replacement, Hip*
  • Aspirin / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Ossification, Heterotopic / drug therapy*
  • Ossification, Heterotopic / prevention & control*
  • Osteoarthritis, Hip / surgery*
  • Prevalence
  • Retrospective Studies
  • Severity of Illness Index*
  • Thrombosis / prevention & control
  • Warfarin / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticoagulants
  • Warfarin
  • Aspirin