Long term sequelae of childhood acute bacterial meningitis in a developing country. A study from the Sudan

Scand J Infect Dis. 1991;23(2):175-82. doi: 10.3109/00365549109023397.

Abstract

35 survivors of acute bacterial meningitis (ABM) from a group of 44 Sudanese children--seen during 18 months (April 1985-November 1986)--were prospectively followed to ascertain the long-term sequelae of the disease. 30 (17 with Haemophilus influenzae, 8 Neisseria meningitidis, 4 Streptococcus pneumoniae and one child with Enterobacter cloacae meningitis) could be followed during the surveillance period (3-4 years). Three (10%), including 2 with hemiplegia, died after 11-12 months. The association between motor deficit on discharge from hospital and subsequent death was significant (p = 0.04). Of the remaining 27, neuropsychologic sequelae were recorded in 9 (33%). Sensorineural hearing loss was observed in 6 (22%) patients and improved in one during surveillance. Motor deficits were found to improve with time but were replaced by the development of epilepsy about 3 years later in 11% of the survivors. The mean IQ (+/- SD) score for a subgroup of 19 post-meningitic children (92.3 +/- 13.9) was found to be significantly lower than in their nearest-age sibling controls (100.7 +/- 10.2; p = less than 0.01). Younger age at admission and longer duration of ABM symptoms before treatment were significantly associated with poorer outcome (respectively, r = 0.63, p = less than 0.01, r = 0.67, p = less than 0.01). The potential impact of vaccination against the commonest organisms causing ABM in developing countries is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Deafness / etiology*
  • Female
  • Follow-Up Studies
  • Hemiplegia / etiology*
  • Humans
  • Intelligence Tests
  • Male
  • Meningitis / complications*
  • Meningitis, Haemophilus / complications
  • Meningitis, Meningococcal / complications
  • Meningitis, Pneumococcal / complications
  • Motor Neurons*
  • Prospective Studies
  • Psychometrics
  • Sudan
  • Time Factors