Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba

Koichiro Koyama; Yusuke Hirasawa; Kazumasa Zaima; Teh Chin Hoe; Kit-Lam Chan; Hiroshi Morita

doi:10.1016/j.bmc.2008.05.033

Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba

Bioorg Med Chem. 2008 Jul 1;16(13):6483-8. doi: 10.1016/j.bmc.2008.05.033. Epub 2008 May 20.

Authors

Koichiro Koyama¹, Yusuke Hirasawa, Kazumasa Zaima, Teh Chin Hoe, Kit-Lam Chan, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.

PMID: 18524603
DOI: 10.1016/j.bmc.2008.05.033

Abstract

Five new alkaloids, alstilobanines A (1)-E (5) were isolated from Alstonia angustiloba (Apocynaceae) and their structures were determined by MS and 2D NMR spectral analysis. Alstilobanines A-E showed a moderate vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alstonia / chemistry*
Animals
Indole Alkaloids / chemistry*
Indole Alkaloids / pharmacology*
Magnetic Resonance Spectroscopy
Male
Models, Molecular
Molecular Structure
Rats
Rats, Wistar
Structure-Activity Relationship
Vasodilation / drug effects

Substances

Indole Alkaloids