"Self-activating" chemical nuclease: ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant

Kun Li; Li-Hong Zhou; Ji Zhang; Shan-Yong Chen; Zhong-Wei Zhang; Jing-Jing Zhang; Hong-Hui Lin; Xiao-Qi Yu

doi:10.1016/j.ejmech.2008.03.029

"Self-activating" chemical nuclease: ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant

Eur J Med Chem. 2009 Apr;44(4):1768-72. doi: 10.1016/j.ejmech.2008.03.029. Epub 2008 Apr 4.

Authors

Kun Li¹, Li-Hong Zhou, Ji Zhang, Shan-Yong Chen, Zhong-Wei Zhang, Jing-Jing Zhang, Hong-Hui Lin, Xiao-Qi Yu

Affiliation

¹ Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, No. 29, Wangjiang Road, Chengdu, Sichuan 610064, PR China.

PMID: 18524424
DOI: 10.1016/j.ejmech.2008.03.029

Abstract

The interactions of cyclen Cu(II) complexes functionalized by ferrocenyl group with plasmid DNA indicated that these complexes have high cleavage efficiency via an oxidative mechanism in the absence of any reductant or oxidant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Copper / chemistry*
DNA / metabolism*
DNA Cleavage / drug effects*
Ferrous Compounds / chemistry*
Indicators and Reagents / chemical synthesis
Indicators and Reagents / chemistry
Indicators and Reagents / metabolism
Indicators and Reagents / pharmacology
Ligands
Metallocenes
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Organometallic Compounds / metabolism*
Organometallic Compounds / pharmacology*
Reducing Agents / metabolism

Substances

Ferrous Compounds
Indicators and Reagents
Ligands
Metallocenes
Organometallic Compounds
Reducing Agents
Copper
DNA
ferrocene