The most important bibliography on the role of genetics in personality and its disorders has been reviewed from a clinical point of view. Following the introduction, the most relevant findings on genetics and the personality dimensions are compiled, focusing on Cloninger's Psychobiological Model. Regarding personality disorder, studies have been found on cluster A, mainly related to the schizotypal personality disorder, and on cluster B, mainly related to antisocial personality and borderline disorders. The bibliography on cluster C PD was limited. The review concludes with a discussion that stresses the possible usefulness of personality dimensions, considered as interphenotypes regarding both diagnostic aspects and treatment.