Abstract
Bioassay-guided purification from the seeds of Peganum harmala led to the isolation of harmine (1), harmaline (2), vasicinone (3), and deoxyvasicinone (4). Harmine (1) and harmaline (2) showed a moderate in vitro antiplasmodial activity against Plasmodium falciparum. Quinazoline alkaloid, vasicinone (3), showed a vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Antimalarials / isolation & purification
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Antimalarials / pharmacology
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Harmaline / isolation & purification
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Harmaline / pharmacology
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Harmine / isolation & purification
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Harmine / pharmacology
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Peganum / chemistry*
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Phenylephrine
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects
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Quinazolines / isolation & purification
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Quinazolines / pharmacology
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Rats
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Seeds
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Vasodilation / drug effects
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology
Substances
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Alkaloids
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Antimalarials
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Plant Extracts
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Quinazolines
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Vasodilator Agents
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Phenylephrine
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Harmine
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2,3-trimethylene-4-quinazolone
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Harmaline
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vasicinone