As semi-automated measurement would be desirable for lesion quantification and therapy-response control, the purpose of this study was to compare semi-automated measurements with manual assessment of different types of hepatic metastases. Seventy-six patients with known liver metastases were analysed. All of them underwent contrast-enhanced 16-MDCT (16 x 0.75 mm collimation, 120 kV, 0.5 s rotation time, 160 mAs(eff)) for evaluation of follow-up status. On the basis of standard reconstructed 5-mm slices (in 4-mm increments), each lesion was quantified based on RECIST and WHO criteria using a semi-automated software tool (Syngo Oncology) and also manually by an experienced radiologist. Results from the software were compared to manual measurements. Statistical analysis was performed applying the concordance correlation coefficient, and results were represented graphically in Bland-Altman plots. A total of 52 hyperdense, 57 hypodense and 56 heterogeneous metastases were found and correctly measured by the software. All three lesion types revealed a strong correlation agreement between measurement techniques [RECIST diameter: 0.93 (hyperdense), 0.95(hypodense), 0.94 (heterogeneous); WHO area: 0.95, 0.98, 0.93]. Semi-automatic measurement of hyperdense, hypodense and heterogeneous liver metastases showed reliable results on standard axial reconstructions in comparison to manual quantification.