ER biogenesis: self-assembly of tubular topology by protein hairpins

Curr Biol. 2008 Jun 3;18(11):R474-6. doi: 10.1016/j.cub.2008.04.031.

Abstract

The structure of the endoplasmic reticulum (ER) depends on members of the reticulon and DP1/Yop1p families. Two of these proteins are sufficient to form tubular membrane networks from pure phospholipid vesicles, thus revealing a new paradigm of ER morphogenesis.

MeSH terms

  • Endoplasmic Reticulum / metabolism*
  • Membrane Proteins / metabolism*
  • Membrane Transport Proteins / metabolism
  • Models, Biological
  • Phospholipids / metabolism*
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Membrane Proteins
  • Membrane Transport Proteins
  • Phospholipids
  • Rtn1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • YOP1 protein, S cerevisiae