A common polymorphism is associated with body mass index in Uyghur population

Diabetes Res Clin Pract. 2008 Aug;81(2):e11-3. doi: 10.1016/j.diabres.2008.03.022. Epub 2008 Jun 2.

Abstract

We aimed at observing the association of a common genetic variant near the INSIG2 gene (rs7655505) with body mass index (BMI) related obesity in a population-based association study in Uyghur population. We observed a significant association of rs7566605 polymorphism with BMI related obesity in Uyghurs with an odds ratio of 1.47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Body Mass Index*
  • China
  • Gene Frequency
  • Genotype
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Membrane Proteins / genetics*
  • Obesity / genetics
  • Odds Ratio
  • Polymorphism, Genetic*
  • Regression Analysis

Substances

  • INSIG2 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins