Diapolycopenedioic acid xylosyl esters A, B, and C, novel antioxidative glyco-C30-carotenoic acids produced by a new marine bacterium Rubritalea squalenifaciens

Kazutoshi Shindo; Emiko Asagi; Aya Sano; Eri Hotta; Noriko Minemura; Kanae Mikami; Emiko Tamesada; Norihiko Misawa; Takashi Maoka

doi:10.1038/ja.2008.28

Diapolycopenedioic acid xylosyl esters A, B, and C, novel antioxidative glyco-C30-carotenoic acids produced by a new marine bacterium Rubritalea squalenifaciens

J Antibiot (Tokyo). 2008 Mar;61(3):185-91. doi: 10.1038/ja.2008.28.

Authors

Kazutoshi Shindo¹, Emiko Asagi, Aya Sano, Eri Hotta, Noriko Minemura, Kanae Mikami, Emiko Tamesada, Norihiko Misawa, Takashi Maoka

Affiliation

¹ Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, Japan. kshindo@fc.jwu.ac.jp

PMID: 18503197
DOI: 10.1038/ja.2008.28

Abstract

Novel acyl glyco-carotenoic acids, diapolycopenedioic acid xylosyl esters A, B, and C, were isolated as red pigments by using chromatographic methods from a marine bacterium, Rubritalea squalenifaciens, belonging to subdivision 1 of Verrucomicrobia. The structures of these diapolycopenedioic acid xylosyl esters were determined to be 4-[2-O-acyl-beta-D-xylopyranosyl] hydrogen 4,4'-diapo-Psi,Psi-carotene-4,4'-dioate by spectroscopic analysis. Diapolycopenedioic acid xylosyl ester A showed potent antioxidative activity in a (1)O(2) suppression model.

MeSH terms

Antioxidants / chemistry
Antioxidants / metabolism*
Antioxidants / pharmacology*
Bacteria / chemistry*
Carotenoids / chemistry
Carotenoids / metabolism*
Carotenoids / pharmacology*
Fermentation
Indicators and Reagents
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Seawater / microbiology
Spectrometry, Mass, Electrospray Ionization

Substances

Antioxidants
Indicators and Reagents
diapolycopenedioic acid xylosyl ester A
diapolycopenedioic acid xylosyl ester B
diapolycopenedioic acid xylosyl ester C
Carotenoids